Curcum (Active Turmeric) & Hyaluronic Acid Support Supplement

A complementary feed supplement for horses containing highly bioavailable Curcumin combined with Hyaluronic acid. It can be fed to horses as a nutritional adjunct.

CURCUMIN

ACTIVE TURMERIC

Curcumin is the active component of turmeric, a well-known spice with antioxidant properties and provides support for the digestive, musculoskeletal and immune systems. Turmeric contains approximately 1.6-3.3% curcumin and is poorly absorbed in the body whereas the Curcumin content of the active material in Kurasyn 360X contains 14% Curcumin, and is many times more bioavailable.


HOW CURCUMIN WORKS & BIOAVAILABILITY

A complementary feed supplement for horses containing highly bioavailable Curcumin combined with Hyaluronic acid. It can be fed to horses as a nutritional adjunct.

Curcumin is the active component of turmeric, a well-known spice with antioxidant properties and provides support for the digestive, musculoskeletal and immune systems. Turmeric contains approximately 1.6-3.3% curcumin and is poorly absorbed in the body whereas the Curcumin content of the active material in Kurasyn 360X contains 14% Curcumin, and is many times more bioavailable.

KURASYN 360X - CURCUMIN IN THE GUT

A delivery strategy such as encapsulating curcumin with natural oligosaccharides improves aqueous solubility, dispersibility and absorption. The unique three-dimensional structure of this oligosaccharide creates an inner hydrophobic cavity which transports curcumin molecules to the intestines. The hydrophilic exterior, on the other hand, ensures compatibility in aqueous systems.

Curcumin is transported unchanged through the stomach into the upper intestinal tract where the curcumin molecules are absorbed into the body through the epithelial cell membrane.

A bioavailability study using the curcumin included in KURASYN 360X showed that Curcumin was 85 times more efficiently absorbed into the blood, compared to standard curcumin powder derived from Turmeric.

POTENT ANTI-OXIDANT FOR MUSCLE & EXERCISE RECOVERY

High level competition and heavy training causes an increase in muscle and joint soreness. This can limit performance in training and subsequently in competition.

Many studies have demonstrated that intense exercise produces considerable amounts of reactive oxygen species (ROS). The production of ROS as a result of exercise has been linked to muscle damage and soreness. During physical exercise, oxygen flux to active skeletal muscles increases, which leads to excess production of ROS, free radicals and eventually oxidative stress. (Kinnunen et al 2005).

Oxidative stress as a result of exercise has been well documented in horses and has been associated with decreased physical performance, muscular fatigue, muscle damage, and overtraining. In order to prevent oxidative stress, the body contains a large network of antioxidants that either prevent ROS formation or scavenge free radicals.

Strenuous physical exercise, where the consumption of oxygen is increased can result in a state of oxidative stress. (Fisher Wellman and Bloomer 2009b). Defense mechanisms that cope with oxidative stress depends primarily on the synergism between several endogenous and dietary antioxidants. (Sen et al. 2000).

Curcumin has remarkable antioxidant activity and its main mode of action of is via free-radical scavenging. It has shown to be more effective than Vitamin C and Vitamin E and superoxide dismutase (Sharma OP). At the same concentration it has about twice the antioxidative activity of the polyphenol resveratrol (Aftab & Viera).


HYALURONIC ACID

Hyaluronic acid is distributed widely throughout the body and is found in connective, epithelial and neural tissues. It is one of the main components of the extracellular matrix in the joint. Hyaluronic acid is responsible for the viscosity and lubricating properties of synovial fluid ensuring correct and smooth movement of the joint.

Its function is to bind water and to lubricate movable parts of the body such as joints and muscles. In the cartilage matrix, aggrecan is the major proteoglycan, it binds with Hyaluronic acid and link proteins and provides a gel structure that gives the cartilage its load-bearing properties (Kiani et al 2002). Hyaluronic acid also acts as an efficient scavenger of free radicals and cellular debris in the joints (Laurent et al 1996, 1995).

A study in the Rood and Riddle Equine hospital in Lexington reported that oral HA reduced joint effusion post operatively following arthoroscopic removal of an OCD lesion in the tarsocrural joint. In another study, horses supplemented daily with 100mg of oral hyaluronic acid showed improved soundness in all parameters.

There are many types of Hyaluronic acid: purified HA from rooster comb, hydrolysed chicken cartilage; however they do not match the biological properties of native HA found in the body. Hyaluronic acid used in KURASYN 360X is purified HA derived from microbial fermentation and is almost identical to native HA.

There is published evidence of oral absorption, the Journal of Agriculture Food and Chemistry investigated the uptake of hyaluronic acid in animals. The study demonstrated that Hyaluronic acid is absorbed into the bloodstream and tissues, especially connective tissues after oral ingestion of purified HA derived from microbial fermentation.

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